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KMID : 1134820080370030288
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 3 p.288 ~ p.293
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Effect of Growth Inhibition and Quinone Reductase Activity Stimulation
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Shin Mi-Ok
Kang Dae-Yeon
Kim Mi-Hyang
Bae Song-Ja
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Abstract
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In this study, we investigated the anticancer activity of Makgeoly (MG). MG was fractionated into four fractions
by using solvent partition method, affording hexane (MGH), methanol (MGM), butanol (MGB) and aquous (MGA)
soluble fractions. We determined the cytotoxicity of these four fractions in four kinds of cancer cell lines, such
as HepG2, MCF-7, B16-F10 and HT29 by MTT assay. Among the various fractions, the MGM showed the strongest
cytotoxic effects on all cancer cell lines. The morphological changes such as membrane shrinking and blebbing
of cells were also observed by MGM treatment in HepG2 cell. In addition, we observed quinone reductase (QR)
activity stimulating effects in all fraction layers of MG on HepG2 cells. QR activity increased approximately 2.6
and 2.1 times in MGM and MGH treated HepG2 cell at 100 μg/mL, respectively, compared to that in control value.
Although further studies are needed, the present work could suggest that the fin of MG has a potential to be used
as a chemopreventive agent against cancer.
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KEYWORD
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cytotoxicity, quinone reductase, Makgeoly (MG)
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